WebNational Center for Biotechnology Information WebMar 10, 2024 · The authors describe a method for DNA target recognition and signal amplification that is based on the target-induced formation of a three way junction. The subsequent assembly of two DNA probes releases the inhibitory strand and triggers a downstream strand displacement amplification.
Cofactor-assisted three-way DNA junction-driven strand …
WebApr 12, 2024 · Pancreatic ductal adenocarcinoma (PDAC), an aggressive and lethal cancer with 5-year overall survival of 10%, is the seventh leading cause of cancer death worldwide [1, 2].Most patients are diagnosed in the advanced stage too late for curable operation; thus, systemic therapy is essential [].As living drugs, chimeric antigen receptor (CAR-T) … WebMar 14, 2011 · DNA three-way junctions are frequently used in nanoarchitectures. Ligand-dependent designs that provide well-characterized building blocks for structure-switching DNA nanodevices are presented. Supporting Information Experimental methods and additional data. This material is available free of charge via the Internet at … colt mustang 380 specs
Naturally occurring three-way junctions can be …
WebWe show that ligand-binding aptamers and fluorogenic aptamers can be inserted into three-way junctions and connected in a way that enables the three-way junction to function as a small-molecule-regulated fluorescent sensor in vitro and in cells. WebOct 20, 2013 · To address this issue, Li et al. further developed a binding-induced three-way junction (TWJ) strategy, 26 where binding-induced DNA assembly and strand displacement were combined with favored ... Web1 day ago · Galectin-3 is a galactoside-binding protein that is commonly overexpressed in many epithelial cancers. It is increasingly recognized as a multi-functional, multi-mode promoter in cancer ... colt mustang 380 stainless magazines