2024 Bsj-4-116

Bsj-4-116

Author: eqse

August undefined, 2024

WebBSJ-4-116 (10-10000 nM; 72 hours) exhibits potent antiproliferative effects in Kelly CDK12C1039F[1]. BSJ-4-116 (50 nM; 6-24 hours) decreases the level of CDK12 protein, regardless of the mutational status of the cell line [1] .

BSJ-4-116 PROTAC CDK12 蛋白降解剂 MCE - MCE …

WebJan 14, 2024 · Chemsrc provides BSJ-03-123(CAS#:2361493-16-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of BSJ-03-123 are included as well. CAS Number Search Sign In WebMoreover, BSJ-4-116 exhibited potent antiproliferative effects, alone and in combination with the poly(ADP-ribose) polymerase inhibitor olaparib, as well as when used as a single … how old does a cow live

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WebBSJ-4-116 is a potent, CDK12 specific degrader (PROTAC) with IC50 of 6 nM, exhibits anti-proliferative activity in cancer cells; BSJ-4-116 demonstrates a low nanomolar IC50 for … WebBSJ-4-116 is a specific degrader of cyclin-dependent kinase 12 (CDK12). BSJ-4-116 exhibits potent antiproliferative effects. Conversion of different model animals based on BSA … WebSolubility: Soluble to 100 mM in DMSO. Purity: ≥98%. Storage: Store at -20°C. The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. Tocris products are intended for laboratory research use … how old does a chinchilla live

BSJ-4-116 ≥99%(HPLC) Selleck CDK inhibitor

Sample Name: F14508S985901BSJ-4-116

WebBSJ-4-116 is a specific degrader of cyclin-dependent kinase 12 (CDK12). BSJ-4-116 exhibits potent antiproliferative effects. Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines) WebApr 10, 2024 · Marcus Smart vs 76ers 4/4/23 Photo by Jesse D. Garrabrant/NBAE via Getty Images. ... Boston Sports Journal BSJ Game Report: Celtics 120, Hawks 116 - Pritchard triple-double seals 57-win season mercedes r230 cabin filterWebBSJ-4-116 是由 Cereblon 配体和 CDK 配体相连的 PROTAC。BSJ-4-116 是一种高效且选择性的 CDK12 降解剂，IC50 为 6 nM。BSJ-4-116 通过提前终止转录来下调 DDR 基因，主要是通过增加聚腺苷酸化。BSJ-4-116 单独或与聚(ADP-核糖)聚合酶抑制剂 Olaparib (HY-10162) 联合使用时表现出有效的抗增殖作用。 mercedes r172 buckle

"WebJul 13, 2024 · BSJ-4-116 overcomes CDK12 C1039F mutation. Furthermore, BSJ-4-116 represents the first example of resistance to a bivalent degrader molecule. It is a … " - Bsj-4-116

Bsj-4-116

WebBSJ-4-116 is a specific degrader of cyclin-dependent kinase 12 (CDK12). BSJ-4-116 exhibits potent antiproliferative effects. Quality confirmed by NMR & HPLC. See customer … WebBSJ-4-116: Catalog Number: M21040: CAS Number: 2519823-34-6: 1.2 Relevant identified uses of the substance or mixture and uses advised against; Identified uses: For research use only, not for human or veterinary use. 1.3 Details of the supplier of the safety data sheet; Company: Abmole Bioscience Inc. 8300 Cypress Creek Parkway, Suite 450 ...

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http://www.bcpchemlab.com/2519823-34-6-BCP40986-cn WebJan 16, 2024 · BSJ-4-116 exhibits potent antiproliferative effects, alone and in combination with the poly(ADP-ribose) polymerase inhibitor Olaparib (HY-10162). Research Area： Cancer Targets： CDK PROTACs

WebMoreover, BSJ-4-116 exhibited potent antiproliferative effects, alone and in combination with the poly(ADP-ribose) polymerase inhibitor olaparib, as well as when used as a single agent against cell lines resistant to covalent CDK12 inhibitors. Two point mutations in CDK12 were identified that confer resistance to BSJ-4-116, demonstrating a ... WebLS4SJ-16 — M24643/43 Mil-Spec Shipboard Cable. Our LS4SJ-16 cable is part of our line of Mil-Spec Shipboard Cable. This 16 AWG cable features four tinned copper …

WebBiological Activity for BSJ-4-116. BSJ-4-116 is a selective CDK12 PROTAC ® Degrader. BSJ-4-116 selectively degrades CDK12 over a panel of other kinases and exhibits no … WebPreparing Stock Solutions for BSJ-4-116-NC. The following data is based on the product molecular weight 851.42. Batch specific molecular weights may vary from batch to batch …

WebProduct name : BSJ-4-116 Catalog No. : HY-139039 CAS No. : 2519823-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, manufacture of substances. 1.3 Details of the supplier of the safety data sheet Company: MedChemExpress USA Tel: 609-228-6898 Fax: 609-228-5909

WebSample Name: F14508S985901BSJ-4-116 Page 1 of 1. Created Date: 6/18/2024 12:35:08 PM ... how old does a dog have to be to be adoptedWebDescription: Negative control for BSJ-4-116 (Cat. No. 7528) Chemical Name: N -[7-[(3 R )-3-[[5-Chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-1 … mercedes r320 reset maintenance lightWebModel: SPJ-716-14 Shown: Matte Bronze Material: Solid Brass or Copper Finish: Specify Electrical: 12V Engine: FB-TAB-6W Lumens: 300 Color Temp: 2700K Mounting: Direct … mercedes r230 rear shelf bag luggageWebMoreover, BSJ-4-116 exhibited potent antiproliferative effects, alone and in combination with the poly(ADP-ribose) polymerase inhibitor olaparib, as well as when used as a single agent against cell lines resistant to covalent CDK12 inhibitors. how old does a gun have to be for a curioWebBSJ-4-116. BSJ-4-116 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. … how old does a cosigner have to beWebOutput module BSJ-310. Output module with 8 open transistor (collector), non-monitored outputs. The output module provides eight open collector, non-monitored outputs for internal relay or LED operation in a cabinet. The module is easily plugged onto a mounting rail inside the AutroSafe fire alarm control panel BS-420 or the controller BC-420. how old does a duck have to be to quackWebSend up to 1 Amp DC and up to 50 Volts DC down a coax cable to power equipment (automatic antenna tuner, relay box, etc.) without running a separate power cable. … how old does a dachshund have to be to breed