WebJul 7, 2011 · CD48 was previously identified as broadly expressed on differentiated hematopoietic cells, but excluded from quiescent long-term HSCs (LT-HSCs). 3, 8 CD48 … WebFeb 2, 1999 · CD48 is a glycosylphosphatidylinositol-anchored, 45- to 50-kDa molecule whose expression is tightly regulated and restricted to lymphocytes, macrophages, and …
Supplementary Materials for - Science
WebSep 19, 2016 · Two independent CD48 KO 721.221 derivatives were generated using two unrelated guide RNA targeting sequences. Control siRNA-transduced YT-S showed little … WebCD48 KO mice have normal T cells. Related to Fig 2. (A)Relative ratios of mean fluorescence intensity (MFI) for staining with Fc fusion proteins over staining with Abs against the indicated molecules on CD2 KO or CD48 KO CD4+T cells, compared with WT CD4+T cells. Values were set as 1.0 for WT cells. NA, not applicable. sci trust accounting
PI3-kinase deletion promotes myelodysplasia by dysregulating …
WebThe CD48 molecule is a glycosyl-phosphatidyl-inositol (GPI)-anchored cell-surface protein of the CD2 family of molecules. Originally described on virally-induced B cells, CD48 has been found on various hematopoietic cells, and its expression is regulated by viral and bacterial products and immune-associated proteins. WebNov 3, 2024 · CD48 activates NK cells through ligation of 2B4 on the NK cells, 11 which was well characterized using the YT1–NK cell line previously. 14 CD48 obtained the strongest enrichment score among all known 27 NK-cell receptor ligands in our sgRNA library ( Figure 1 D; supplemental Figure 1B). WebThe gene for CD48 is located in chromosome 1q 23 and contains 4 exons, each exon encoding one of the 4 domains of CD48: signal peptide, variable (V) domain, constant 2 (C2) domain and the glycophosphatidylinositol anchor ( GPI anchor ). The cDNA sequence of 1137 nucleotides encodes a 243 amino acid polypeptide of about 45 kDa. prayer piggy bank and card