2024 Cinnamic acid inhibition cancer cells

Cinnamic acid inhibition cancer cells

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August undefined, 2024

WebMay 23, 2013 · The growth inhibition was probably associated with DNA damage leading to DNA synthesis inhibition, as shown by BrdU incorporation assay, induction of nuclear aberrations and then apoptosis. The frequency of cell death caused by cinnamic acid was higher in HT-144 cells. WebCA treatment increased the levels of lipid peroxidation in Hela and ME-180 cells. Among all the concentrations (30, 40, and 50 μg/ml) tested, 50 μg of CA showed maximum levels of thio-barbituric acid reactive substances (TBARS), CD, and LHP in HeLa and ME-180 cells (Figure 73.5).Pro-oxidant activity of hydroxycinnamic acids on DNA damage and lipid …

Coumaric and Cinnamic Acids in Food SpringerLink

Webp-Coumaric acid (pCA) is a hydroxycinnamic acid derivative commonly found in many natural products that has been extensively studied for its anticancer activity in multiple … Webp-Coumaric acid (pCA) is a hydroxycinnamic acid derivative commonly found in many natural products that has been extensively studied for its anticancer activity in multiple cell lines.In this report we investigated the effects of this phytochemical as adjuvant therapy to treat glioblastoma, an infaust brain tumour characterized by the acquired or innate … easy homemade family recipes

Synthesis of cinnamic acid ester derivatives with ... - ScienceDirect

WebNov 30, 2024 · A search for naturally occurring HDAC inhibitors continues due to the adverse effects associated with known HDAC inhibitors like SAHA and TSA. Therefore … WebPrevious studies have shown that trans-cinnamic acid (tCA) has a broad spectrum of biological activities, and exhibits antioxidant, anti-inflammatory and anticancer properties. … WebSep 25, 2013 · Interestingly, cinnamic acid also exhibits anti-cancer activity in the cancer stem cells. Huang et al. (2012)examined the effect of cinnamic acid in lung cancer stem cells.... easy homemade hawaiian rolls

Growth Inhibition of Human Breast and Prostate …

Cinnamic acid derivatives induce cell cycle arrest in carcinoma cell ...

WebOct 21, 2024 · Incubation of human colorectal cancer cells in the presence of cinnamic acid at concentration higher than 10 mM resulted in reduced cell viability (IC50 13.6 mM). ... The mechanism is attributed to the lower expression of some drug resistance proteins, inhibition of cell proliferation, and promotion of apoptosis (Lu et al. 2024). WebFig. 1. Chemical Structure of Cinnamic Acid Derivatives Fig. 2. Growth Inhibition with Cinnamic Acid Derivatives MCF-7 (A and B) and PC-3 (C and D) cells were treated … easy homemade honey wheat bread recipeWebMar 25, 2015 · Although one of the best characterized inhibitors, α-cyano-4-hydroxycinnamic acid (α-CCA), possesses a 10-fold selectivity for MCT1 compared to other subtypes (Figure 1) [22], it also shows ... easy homemade cranberry sauce recipe

"WebDec 19, 2024 · Inflammation and oxidative stress are involved in cardiovascular diseases. Nitrogen monoxide participates in the regulation of endothelial processes. Thus, derivatives of classic nonsteroidal anti-inflammatory drugs (NSAIDs), trolox or cinnamic acids esterified with 2-(nitrooxy)ethanol were designed and studied. It was found that the nitrogen … " - Cinnamic acid inhibition cancer cells

Cinnamic acid inhibition cancer cells

Growth Inhibition of Human Breast and Prostate Cancer Cells by Cinnamic ...

WebAbstract. p-Coumaric acid (pCA) is a hydroxycinnamic acid derivative commonly found in many natural products that has been extensively studied for its anticancer activity in … WebJul 24, 2010 · Conclusion: Our study suggests that anti-tumor effect of cinnamon extracts is directly linked with enhanced pro-apoptotic activity and inhibition of NFkappaB and AP1 …

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WebNov 30, 2024 · The anti-cancer activity of cinnamic acid derivatives was measured according to Madhunapantula et al., 2008 . 0.5 x 10 4 colon (HCT-116 and HCT-15) and … WebJul 1, 2024 · In the current study, we show the inhibitory effects of cinnamic acid derivatives, including caffeic acid phenethyl ester (CAPE, 1), on the growth of breast and prostate cancer cells. Among the compounds examined, 3,4,5-trihydroxycinnamic acid …

WebBackground & objective: Recently, the research showed that cinnamic acid (CINN) could inhibit some cancer cells. This study was designed to investigate the effects of alpha … WebBackground/aim: Breast cancer is the second leading cause of cancer-related deaths in US, which necessitates constant research for medications with minimal adverse effects. …

WebCA can inhibit the growth of leukaemia cells by inducing cell apoptosis and significantly affected the cell cycle after 48 h treatment, resulting in increased G0/G1 phase and extension of thecell cycle in the tumour cells. This study aims to investigate the effect and mechanism of action of cinnamic acid (CA) on the proliferation and apoptosis of … WebJan 15, 2009 · Here, we demonstrate that the cinnamon-derived dietary Michael acceptor trans-cinnamic aldehyde (CA) impairs melanoma cell proliferation and tumor growth. …

WebApr 12, 2024 · Naproxen is widely used for anti-inflammatory treatment but it can lead to serious side effects. To improve the anti-inflammatory activity and safety, a novel naproxen derivative containing cinnamic acid (NDC) was synthesized and used in combination with resveratrol. The results showed that the combination of NDC and resveratrol at different …

WebJul 18, 2024 · The antioxidant and biological activities of Physalis peruviana have been reported in extracts of the calyxes, leaves, stems, and merely in fruits. These extracts have been shown to inhibit the growth of different cancer cell lines and exhibit protective effects in liver and other cells, as well as exhibit anti-inflammatory activity. 11,12 Some studies … easy homemade fajita seasoning recipeWebApr 1, 2024 · We synthetized seventeen cinnamates derived from trans -cinnamic acid. • The Steglich esterification reaction was the main step involved in their synthesis. • The most effective compound 3q reduced the melanoma cell viability. • Compound 3q caused cell cycle arrest and apoptosis in B16-F10 cells. • easy homemade hard rolls tmhWebJul 28, 1995 · We now show that cinnamic acid induces cytostasis and a reversal of malignant properties of human tumor cells in vitro. The concentration causing a 50% … easy homemade egyptian kebabs recipeWebBackground: Berberine and cinnamic acid are natural compounds that exhibit potent anticancer activities through distinct molecular mechanisms. Objective: In the present study, we aimed to investigate the proapoptotic potential of cinnamic acid and berberine in cancer cells by examining their effect on the expression of proapoptotic and antiapoptotic genes. easy homemade flaky pie crust with butterWebFeb 26, 2024 · Propolis extract or components was reported to be cytotoxic to several cancer cells [20, 21] and to induce autophagy in breast cancer cells [9].In order to elucidate whether and what kind of propolis components exhibits the above actions on prostate cancer CWR22Rv1 cells, the cytotoxic effects of eight cinnamic acid … easy homemade foot soakWebCinnamic acid containing an aryl ring with α, β-unsaturated ketone, was reported to have anticancer activity. Therefore, both chalcone and cinnamic acid have been adapted as versatile structural moieties in many cases of cancer drug development [ 30 ]. easy homemade french onion dipWebTo design & optimize trans-cinnamic acid loaded PLGA nanoparticles & assess its inhibitory effect on epithelial-mesenchymal transition triple-negative BC. ... the Impact of Optimized Trans-Cinnamic Acid-Loaded PLGA Nanoparticles on Epithelial to Mesenchymal Transition in Breast Cancer . Fulltext; Metrics; Get Permission; Cite this article; easy homemade dog treats pumpkin