Ferm domain containing 3
WebMar 21, 2024 · Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner. Eysert F, et al. Mol Psychiatry, 2024 Oct. PMID 33144711, Free PMC Article. See all (133) citations in PubMed. See citations in PubMed for homologs of this gene provided by HomoloGene. WebFERMT1 knockdown reduced microglia activity, inhibited NLR family pyrin domain containing 3 (NLRP3) inflammasome activity and decreased the expression of inflammatory factors including interleukin-1β (IL-1β) and interleukin 18 (IL-18) in …
Ferm domain containing 3
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WebBased on the interaction between PDZ domain-containing SNX27 and PDZ domain-binding motif-containing AQP2, we examined the intracellular localization of FLAG-tagged SNX27 and HA-tagged AQP2 in HeLa cells . Both FLAG-tagged SNX27 constructs (SNX27-Full Length, SNX27-Δ(PX+FERM), SNX27-ΔFERM, and SNX27-ΔPDZ, respectively) and … Ezrin, moesin, and radixin are highly related proteins (ERM protein family), but the other proteins in which the FERM domain is found do not share any region of similarity outside of this domain. ERM proteins are made of three domains, the FERM domain, a central helical domain and a C-terminal tail domain, … See more In molecular biology, the FERM domain (F for 4.1 protein, E for ezrin, R for radixin and M for moesin) is a widespread protein module involved in localising proteins to the plasma membrane. FERM domains are found in a number of See more FERM domain containing proteins include: • Band 4.1, which links the spectrin-actin cytoskeleton of erythrocytes to the plasma membrane. • Ezrin, a component of the undercoat of the See more
WebKindlins are 4.1-ezrin-ridixin-moesin (FERM) domain containing proteins. There are three kindlins in mammals, which share high sequence identity. Kindlin-1 is expressed primarily in epithelial ... WebMar 21, 2024 · FERMT3 (FERM Domain Containing Kindlin 3) is a Protein Coding gene. Diseases associated with FERMT3 include Leukocyte Adhesion Deficiency, Type Iii and Leukocyte Adhesion Deficiency, Type …
WebFeb 22, 2024 · The protein Na +, H +-exchanger 1 (NHE1) contains a positively-charged ERM-binding motif in the C-terminal cytoplasmic tail, which binds to the FERM domain of ezrin . The ERM proteins, especially ezrin, also directly bind to the P-glycoprotein (P-gp), which is a key player in multidrug-resistant phenotypes in cancer. WebWe'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2024 ...
WebThe FERM domain containing adaptor protein Merlin has been shown to act as a tumour suppressor. FERM domains contain three lobes, with the N-terminal lobe resembling …
WebMay 8, 2014 · The protein 4.1R, ezrin, radixin, moesin (FERM) superfamily consists of over 40 proteins all containing a three lobed N-terminal FERM domain which binds a variety of cell-membrane associated proteins and lipids. The C-terminal ends of these proteins typically contain an actin-binding domain (ABD). shell kiss facebookWeb282-427: 1.93e-73: FERM domain C-lobe of Janus kinase 1; JAK1 is a tyrosine kinase protein essential in signaling type I and type II cytokines. It interacts with the gamma chain of type I cytokine receptors to elicit signals from the IL-2 receptor family, the IL-4 receptor family, the gp130 receptor family, ciliary neurotrophic factor receptor (CNTF-R), … spongebob you\\u0027re fired miss puff dadWebThey each contain a bipartite FERM domain comprising four subdomains F0, F1, F2, and F3 that show homology with the FERM head (H) domain of the cytoskeletal Talin … spongebob you\u0027re fired game nickshell kirkby stephenhttp://www.informatics.jax.org/marker/MGI:2442466 shell kislingburyWebMar 21, 2024 · PLEKHH3 (Pleckstrin Homology, MyTH4 And FERM Domain Containing H3) is a Protein Coding gene. Diseases associated with PLEKHH3 include Trachea Adenoid Cystic Carcinoma and Tracheal … shell kinross service stationWebMar 21, 2024 · FRMPD2 (FERM And PDZ Domain Containing 2) is a Protein Coding gene. Diseases associated with FRMPD2 include Wrinkly Skin Syndrome . Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and 1-phosphatidylinositol binding . An important paralog of this gene … spongebob you\u0027re fired miss puff dad