Fsh directly regulates bone mass
WebSep 29, 2024 · Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, Papachristou DJ, et al. FSH directly regulates bone mass. Cell. 2006;125:247–60. Article CAS Google Scholar Legg JA, Herbert JM, Clissold P, Bicknell ... WebJan 16, 2013 · Genetics research in mice by Sun et al. [5] showed that follicle-stimulating hormone (FSH) can stimulate osteoclastic bone resorption through tumor necrosis factor-alpha (TNF-α) and can directly regulate bone mass; moreover, it was suggested that hypogonadal bone loss is caused by high circulating FSH levels and not by declining …
Fsh directly regulates bone mass
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WebApr 1, 2006 · Search worldwide, life-sciences literature Search. Advanced Search WebBone mass is increased and osteoclastic resorption is decreased in haploinsufficient FSHβ +/-mice with normal ovarian function, suggesting that the skeletal action of FSH is …
WebThrough high-affinity receptors, some of which are variants of the ovarian FSH receptor (FSHR), FSH regulates bone mass, adipose tissue function, energy metabolism, and cholesterol production in both sexes. These newly described actions of FSH may indeed be relevant to the pathogenesis of bone loss, dysregulated energy homeostasis, and ... WebOct 1, 2011 · Regarding FSH effects on bone, Sun et al. suggested that FSH directly regulates bone mass in mice by stimulation of osteoclastic differentiation and function both in vitro and in vivo. A clinical study in postmenopausal women [ 14 ] evaluated the influence of FSH receptor polymorphisms gene and concluded that AArs6166 polymorphism …
WebBone mass is increased and osteoclastic resorption is decreased in haploinsufficient FSHβ +/-mice with normal ovarian function, suggesting that the skeletal action of FSH is estrogen independent. Osteoclasts and their precursors possess G i2α -coupled FSHRs that activate MEK/Erk, NF-κB, and Akt to result in enhanced osteoclast formation and ... Webhere establish that FSH regulates osteoclastic bone re-sorption and bone mass directly. RESULTS Hypogonadal FSH Receptor Null Mice Do Not Lose Bone Despite severe …
WebApr 7, 2010 · Hypothalamic gonadotropin-releasing hormone (GnRH) stimulates secretion of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which directly regulate ovarian function. Pituitary FSH can modulate osteoclast development, and thereby influence bone turnover. Pituitary oxytocin and prolactin effects on the skeleton are not …
WebJul 1, 2024 · FSH directly regulates bone mass. Cell. 2006; 125 (2): 247-260. Google Scholar. ... Effects of recombinant follicle-stimulating hormone on bone turnover … jane the virgin cast 2022WebApr 21, 2006 · FSH has thus been regarded as a marker for the onset of menopause ( Prior, 1998 ). However, it has never been tested whether FSH might directly cause the … jane the virgin chapter 44WebMay 1, 2006 · This happens because FSH directly regulates osteoclasts and bone resorption. These two conclusions represent a major shift in two paradigms : first, FSH , like LH ... knockout mice provide evidence that sex hormones can regulate bone mass independent of FSH: double ER null female mice have a low bone mass (Sims et al., … lowest power arm microcontrollerWebApr 25, 2006 · Sun et al. now show that follicle-stimulating hormone (FSH), a pituitary hormone that regulates estrogen production, has a direct effect on bone mass by … jane the virgin chapter 65 release dateWebWe have previously shown that pituitary hormones, such as FSH, can regulate both bone mass and body fat . We studied the action of OXT on body fat in Oxt −/ ... L. Sun et al., FSH directly regulates bone mass. Cell 125, 247–260 (2006). … jane the virgin chapter 65WebFeb 4, 2009 · Thyrotoxicosis is associated with a high-turnover osteoporosis, which has been solely attributed to elevated thyroid hormone levels. Mice lacking the thyroid hormone receptors α and β establish a role for thyroid hormones in regulating bone remodeling. We show that TSH, which falls when thyroid hormones rise, directly suppresses bone … jane the virgin chapter 92 watch onlineWebObese children grow faster than their normal-weight peers. Insulin resistance and hyperinsulinemia have been associated with obesity-related growth acceleration.To determine whether obesity-associated hyperinsulinemia promotes bone growth by activating the insulin receptor in the growth plate, we generated TamCart IR flox /flox mice. The … lowest power cnn chip