Mycn atf4
Web4 nov. 2024 · ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. 01 July 2024. Feven Tameire, Ioannis I. Verginadis, ... Web21 aug. 2014 · Mechanistically, we identified ATF4 as a novel regulator which coordinates with N-Myc to directly activate ASCT2 expression. Of note, ASCT2 expression, which …
Mycn atf4
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Since ATF4 is critical for survival following MYC activation (Fig. 1c–e), we performed chromatin immunoprecipitation with sequencing (ChIP–seq) in DLD-1 MycER cells with or without MYC activation to map genes bound by ATF4 on a genome-wide scale. We identified 330 unique ATF4-binding sites that … Meer weergeven We previously reported that activation of MYC leads to phosphorylation of PERK and eIF2α11. To test whether MYC activation also … Meer weergeven Amino acid deficiency leads to accumulation of uncharged tRNAs, which in turn bind to GCN2, resulting in its autophosphorylation … Meer weergeven Web22 aug. 2024 · ATF4/MYC Regulates MTHFD2 to Promote NSCLC Progression by Mediating Redox Homeostasis . Authors Yixing Gao 1 2 , Lan Feng 3 4 5 , Luping Zhang …
Web1 aug. 2024 · The ability of ATF4 to stabilize MYCN protein also suggests a molecular mechanism for the observation that ATF4 overexpression significantly enhanced the … Web4 apr. 2024 · It might be speculated that in MYCN-non-amplified NB, EIF4EBP1 expression may be regulated by transcription factors other than MYCN. In particular, ATF4, which is critical for the metabolic ...
Web14 mei 2024 · Analysis of patient data reveals significantly higher ATF4 mRNA levels in neuroblastoma tumors with MYCN amplification [80] and higher ATF4 expression is associated with poor prognosis in... Web16 apr. 2024 · G, H Immune blot assessed the protein levels of MYC and ATF4 in OCI-AML3 (p53 wt) and THP-1 (p53 deficiency) cells exposed to LD Triptolide and Nutlin-3a alone or in combination. ns indicates not significant, *p < 0.05, **p < 0.01, ***p < 0.001, colored by corresponding single drug treatment in statistical tests
WebATF4 then activates PUMA and other genes (e.g., NOXA and TRB3) involved in the execution of cell death, sensitizing tumor cells to Myc-mediated apoptosis. Like Myc, ATF4 also plays a dual role in regulating cellular activities. ATF4’s typical role as a protective factor is well documented (. Ameri and Harris, 2008.
Web1 aug. 2024 · MYCN is a member of the MYC family of proto-oncogenes (c-MYC, MYCN, and MYCL), which encode helix-loop-helix-zipper transcription factors that play a pivotal … greek face statueWebATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. The c-Myc oncogene drives malignant progression and induces robust … greek face featuresWeb4 nov. 2024 · Enrichment plot of a reactome gene set representing an ATF4-dependent stress response is shown ( n = 3 biologically independent experiments). Statistical analysis was done as described in Fig.... flow beverage corp sedarWeb8 feb. 2024 · In turn, elevated c-MYC supports ATF4 translational induction by enhancing the expression of the amino acid transporter SLC7A5, increasing the uptake of essential amino acids, and the subsequent maintenance of mTORC1 activity in asparagine-restricted melanoma cells. greek facial features femaleWebMYC activation has also been observed to upregulate ATF4, where ATF4 plays a critical role in supporting cell adaptation and survival during MYC-dependent tumor growth 46, … greek face masksWebThe proteasome inhibitors, which are FDA approved for the first-line treatment of multiple myeloma, emerge as top hits to elicit MYC-mediated synthetic lethality. Proteasome … flow beverage corp. sedarWeb1 aug. 2024 · Given the challenge in therapeutically targeting MYCN directly, we searched for MYCN-activated metabolic pathways as potential drug targets. Here we report that neuroblastoma cells with MYCN amplification show increased transcriptional activation of the serine-glycine-one-carbon (SGOC) biosynthetic pathway and an increased … greek face oil