WebThis study not only establishes CoQ-FSP1 as a new downstream effector of the KEAP1-NRF2 pathway but also provides an additional therapeutic target for treating KEAP1-mutant lung cancer . In summary, NRF2 is an important transcriptional regulator of anti-ferroptosis genes which prevent lipid peroxidation and the accumulation of free iron. WebJun 23, 2024 · (A). Gene editing methods in A549 lung cancer cell lines with NRF2 homozygous knockout (The yellow part represents target sequences; the dotted line …
Keap1 mutation renders lung adenocarcinomas …
WebApr 5, 2024 · Mutated (changed) forms of the SCD1 gene have been found in some types of cancer, including soft tissue sarcoma, non-small-cell lung cancer, endometrial cancer, and others and these play the most crucial role in SCD1 expression and cancer progression [11] (Figure 2 A).Interestingly, the most predominant mutation is missense mutation (Figure … WebJun 8, 2024 · KEAP1-mutant human cancer cells depend on ER-resident genes SLC33A1, SUCO and TAPT1. ... To assess the effects of Slc33a1 targeting in Keap1-wild-type and … meaning of zero sum gain
Targeting NFE2L2 mutations in advanced squamous cell lung …
WebApr 22, 2024 · KEAP1 (kelch-like ECH associated protein 1) is frequently mutated or inactivated in lung cancers, and KEAP1 mutant lung cancers are refractory to most therapies, including radiotherapy. WebJul 5, 2024 · From previous work, our group found that low glutamate levels are a hallmark of KEAP1-mutant tumors, which become very dependent on nutrients such as glutamine. Until recently, there was no good way to target glutamine or other glutamine-consuming enzymes in tumor cells. WebJun 1, 2024 · NFE2L2 mutations occur exclusively in an exon 2 hotspot that encodes the Neh2 domain (aa.1-86), which is the binding site for Keap1. Mutations in this region disrupt Keap1 binding, leading to Nrf2 nuclear translocation and increased mTOR signaling through regulation of RagD (Shibata Cancer Res 2010). meaning of zero math